Catalog Number - 68004-15P

Cogent RP C4 Butyl is a reversed-phase HPLC stationary phase manufactured using high-purity silica with traditional butyl (C4) ligand bonding and complete double endcapping. Classified as USP L26, this stationary phase provides moderate hydrophobic retention for compounds that may be excessively retained on more hydrophobic phases such as C8 or C18 columns. The C4 chemistry is an excellent choice for hydrophobic and neutral analytes when shorter retention times and efficient separations are desired.

68004-15P is a 150 mm x 4.6 mm ID analytical HPLC column packed with 10 µm RP C4 Butyl particles with a 100 Å pore size. The 150 mm column length provides increased resolving power and peak capacity compared to shorter columns, making it well suited for method optimization, impurity investigations, and separations that benefit from enhanced chromatographic resolution. The 10 µm particle size supports higher flow rates while maintaining lower operating backpressure, and the 4.6 mm ID format is the industry standard for conventional HPLC systems, typically operating at approximately 1.0–2.0 mL/min.

This USP L26 column is particularly useful for hydrophobic and neutral compounds requiring less retention than a C8 stationary phase. The combination of fully endcapped C4 chemistry, high-purity silica, and larger particle technology delivers robust chromatographic performance for analytical methods, scale-up studies, and preparative method development.

Key Benefits

• RP C4 Butyl stationary phase

• USP L26 classification

• Fully double endcapped chemistry

• Traditional butyl (C4) bonded phase

• High-purity silica support

• 10 µm particles for lower backpressure

• Suitable for higher flow rates

• Less retention than C8 columns

• Enhanced resolution from 150 mm column length

• Useful for method development and scale-up studies

Typical Applications

• Reversed-phase HPLC

• USP L26 methods

• Hydrophobic compound analysis

• Neutral compound analysis

• Method development

• Impurity investigations

• Preparative method scouting

• Scale-up studies

• Quality control testing

Specifications

• Product Type: HPLC Column

• Stationary Phase: RP C4 Butyl

• USP Classification: L26

• Chromatography Mode: Reversed Phase

• Bonded Phase: Butyl (C4)

• Endcapping: Fully Double Endcapped

• Particle Size: 10 µm

• Pore Size: 100 Å

• Column Dimensions: 4.6 mm ID x 150 mm

• Length: 150 mm

• Recommended Flow Rate: 1.0–2.0 mL/min

• Brand: Cogent

Important Notes

• Designed for reversed-phase chromatography

• Provides less retention than comparable C8 columns

• Suitable for hydrophobic and neutral compounds

• Larger particle size reduces operating backpressure

• Longer column length improves separation of closely related compounds

• Compatible with conventional HPLC systems

• Alternative for many USP L26 methods